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2-Chlorodeoxyadenosine in cutaneous T-cell lymphoproliferative disorders

L R Kong¹, E Samuelson, S T Rosen

¹Department of Medicine, Olson Pavilion, Chicago, Illinois 60611, USA.

Leukemia & Lymphoma

|June 1, 1997

Summary

The study evaluated 2-chlorodeoxyadenosine (2-CdA) for cutaneous T-cell lymphoproliferative disorders. While showing some response, significant toxicities like myelosuppression limit its use.

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Area of Science:

Oncology
Hematology
Dermatology

Background:

Cutaneous T-cell lymphoproliferative disorders (CTLDs) encompass conditions like mycosis fungoides and Sezary syndrome.
Relapsed or refractory cases present significant treatment challenges.

Purpose of the Study:

To assess the efficacy and toxicity of 2-chlorodeoxyadenosine (2-CdA) as a single agent in patients with relapsed or refractory CTLDs.
To determine response rates and identify key adverse events associated with 2-CdA treatment.

Main Methods:

A cohort of 25 patients with relapsed/refractory CTLDs received 2-CdA.
Treatment involved varying durations of intravenous infusion (5-7 days) or bolus injection at 0.1 mg/kg/d.
Cycles were administered every 28 days, with some patients receiving multiple cycles.

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Main Results:

An overall response rate of 24% was observed, including 12% complete responses and 12% partial responses.
Median duration for complete response was 4.5 months and for partial response was 2 months.
The most frequent toxicities were myelosuppression (64%) and infectious complications (64%).

Conclusions:

2-chlorodeoxyadenosine (2-CdA) demonstrates activity in previously treated, relapsed T-cell lymphoproliferative disorders.
Significant myelosuppression and infectious complications necessitate careful monitoring and dose adjustments.