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The alpha v beta 3 integrin "vitronectin receptor"

M A Horton1

  • 1Department of Medicine, Jules Thorn Institute, Middlesex Hospital, London, UK.

The International Journal of Biochemistry & Cell Biology
|May 1, 1997
PubMed
Summary
This summary is machine-generated.

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The alpha v beta 3 integrin, also known as the vitronectin receptor, mediates cell adhesion and is involved in cell signaling. It is upregulated in conditions like angiogenesis and malignancy, with antagonists under development.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • The alpha v beta 3 integrin is a heterodimeric protein belonging to the integrin superfamily.
  • It functions as the vitronectin receptor, mediating cell adhesion to extracellular matrix proteins via the RGD sequence.

Purpose of the Study:

  • To summarize the structural and functional characteristics of the alpha v beta 3 integrin.
  • To highlight its roles in cell adhesion, signal transduction, and cell-cell interactions.
  • To note its expression patterns in specific physiological and pathological conditions.

Main Methods:

  • Review of existing literature on integrin structure and function.
  • Analysis of studies investigating alpha v beta 3 expression and roles.
  • Examination of research on alpha v beta 3 antagonists.

Related Experiment Videos

Main Results:

  • Alpha v beta 3 integrin (160/85 kDa) exhibits typical integrin features.
  • It binds to extracellular matrix via the arg-gly-asp (RGD) sequence.
  • Expression is high in osteoclasts and upregulated in angiogenesis and malignancy.

Conclusions:

  • Alpha v beta 3 integrin plays diverse roles in cell adhesion and signaling.
  • Its involvement in pathological processes like angiogenesis and cancer suggests therapeutic potential.
  • Antagonists targeting alpha v beta 3 are being explored for various diseases.