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Neural hyperplasia in appendix

R Naik1

  • 1Kasturba Medical College, Mangalore.

Indian Journal of Medical Sciences
|December 1, 1996
PubMed
Summary
This summary is machine-generated.

Neurogenous hyperplasia in the appendix is common in patients with appendicular pain. This neural hyperplasia, particularly in the submucosa, was more severe in younger adults (21-40 years).

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Area of Science:

  • Gastroenterology
  • Surgical Pathology
  • Histopathology

Background:

  • Acute appendicular pain is a common surgical presentation.
  • The underlying pathophysiology of appendicular pain is not fully understood in all cases.
  • Neurogenic and neuroendocrine factors may play a role in visceral pain perception.

Purpose of the Study:

  • To investigate the prevalence and characteristics of neurogenous hyperplasia in non-inflamed appendices from patients with acute appendicular pain.
  • To correlate the grade of neural hyperplasia with patient age.
  • To explore the potential role of neural hyperplasia in the etiology of appendicular pain.

Main Methods:

  • Histopathological examination of 150 non-inflamed appendix specimens.
  • Assessment for mucosal and submucosal neurogenous hyperplasia using simple histochemical staining.

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  • Correlation of hyperplasia findings with patient age and clinical presentation.

    • Main Results:

    • Neurogenous hyperplasia was identified in 69.34% of the studied appendices.
    • Submucosal hyperplasia was found to be more severe than mucosal hyperplasia.
    • Higher grades of neural hyperplasia were predominantly observed in patients aged 21 to 40 years.
    • Appendicular pain in three cases without clear pathological findings was potentially linked to neural hyperplasia or associated cell mediators.

    Conclusions:

    • Neurogenous hyperplasia is a frequent finding in appendices associated with acute appendicular pain.
    • The severity and grade of hyperplasia show age-related patterns.
    • Neural hyperplasia, possibly in conjunction with neuroendocrine or mast cell activity, may contribute to appendicular pain, even in the absence of overt inflammation.