Neural hyperplasia in appendix

One hundred fifty histologically non-inflamed appendices from patients with acute appendicular pain were studied for mucosal and submucosal neurogenous hyperplasia using simple histochemical stain. Mucosal and submucosal neural hyperplasia was found in 69.34% of cases. The severity of submucosal hyperplasia was more compared to mucosal. The neural hyperplasia of higher grade was found mainly in the age group between 21 to 40 years. The appendicular pain in three unwarranted surgical cases may be either due to neural hyperplasia or substances liberated from closely associated neuroendocrine/mast cells.