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Published on: October 27, 2009
Platelet aggregation and lipid profile in offsprings of young ischemics
A Khalil1, D Kumar, M Venkatesan
1Department of Pediatrics, Maulana Azad Medical College, New Delhi.
Insights
Platelet aggregation is higher in children of parents with early-onset coronary heart disease (CHD). This finding suggests platelet aggregation may be an early marker for developing CHD.
Area of Science:
- Cardiovascular Medicine
- Pediatric Cardiology
- Clinical Biochemistry
Background:
- Coronary heart disease (CHD) in young adults poses significant health risks.
- Understanding early indicators of CHD risk in offspring is crucial for preventive strategies.
Purpose of the Study:
- To investigate platelet aggregation and lipid profiles in offspring of parents with premature CHD.
- To identify potential early biomarkers for cardiovascular disease risk in younger generations.
Main Methods:
- A cross-sectional, hospital-based study design was employed.
- The study included adults with proven CHD and their offspring, compared to age-matched controls and their offspring.
- Participants underwent screening for lipid profiles and platelet aggregation tests.
Main Results:
- Adults with CHD exhibited significantly higher platelet aggregation compared to controls.
- Offspring of parents with CHD also showed significantly elevated platelet aggregation.
- While adult CHD subjects had abnormal lipid profiles, children in both groups had similar lipid profiles.
Conclusions:
- Enhanced platelet aggregation is observed in offspring of individuals with early-onset CHD.
- Platelet aggregation warrants further investigation as a potential early marker for CHD development.
Objective:
To study the platelet aggregation and lipid profile in offsprings of young ischemic parents.
Design:
Cross sectional.
Setting:
Hospital based.
Methods:
40 adults under 45 years of age with proven CHD and their 50 offsprings comprised the study group. In the control group, 40 age matched adults with normal maximal treadmill test and their 50 off springs were included. All were screened for lipid profile and platelet aggregation.
Results:
Platelet aggregation was significantly elevated in adults with CHD (44.0 +/- 15.5%) compared to controls (32.22 +/- 9.1%). Children of CHD adults also had significantly elevated aggregation (34.9 +/- 12.5%) compared to control offsprings (27.8 +/- 9.9%). Adult CHD subjects had significantly elevated serum cholesterol, LDL-cholesterol (LDL-C) and atherogenic index compared to control adults. The children in both groups had similar lipid profiles.
Conclusion:
Platelet aggregation is enhanced in offsprings of young ischemics. The potential of this index as a marker for early development of CHD needs to be explored.
