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Benign breast dysplasia causing hypercalcemia

S J Marx, R M Zusman, W O Umiker

    The Journal of Clinical Endocrinology and Metabolism
    |November 1, 1977
    PubMed
    Summary
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    A rare case of adolescent hypercalcemia resolved after mastectomy for massive breast enlargement. Benign breast tissue, not parathyroid glands, was implicated in causing high calcium levels.

    Area of Science:

    • Endocrinology
    • Oncology
    • Pathology

    Background:

    • Hypercalcemia in adolescents is uncommon and requires thorough investigation.
    • Massive bilateral breast enlargement can present with complex metabolic disturbances.

    Observation:

    • An adolescent female presented with hypercalcemia and significant bilateral breast enlargement.
    • Initial investigations included neck and mediastinal explorations, revealing normal parathyroid glands.

    Findings:

    • Surgical removal of parathyroid glands did not resolve hypercalcemia.
    • Bilateral mastectomy led to rapid resolution of hypercalcemia, with no recurrence over six years.
    • Microscopic examination of breast tissue showed marked dysplasia, but no malignancy.

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    Implications:

    • This case suggests that benign, dysplastic breast tissue may produce humoral factors causing hypercalcemia.
    • It highlights the importance of considering non-parathyroid sources for hypercalcemia in specific clinical contexts.
    • Further research into breast-derived mediators of calcium metabolism is warranted.