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Pregnancy outcome in systemic sclerosis

A Wanchu1, R Misra

  • 1Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, India.

The Journal of the Association of Physicians of India
|September 1, 1996
PubMed
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Pregnancy in systemic scleroderma (SSc) shows variable outcomes, with no adverse effect on fertility but a decreased live birth rate post-diagnosis. Fetal wastage resulted from both spontaneous abortions and induced terminations.

Area of Science:

  • Rheumatology
  • Obstetrics & Gynecology
  • Maternal-Fetal Medicine

Background:

  • Systemic scleroderma (SSc) is a chronic autoimmune disease affecting connective tissues.
  • Pregnancy in women with SSc presents unique challenges and requires careful management.
  • Understanding the impact of SSc on pregnancy outcomes is crucial for patient care.

Purpose of the Study:

  • To retrospectively analyze the outcomes of pregnancies in women with systemic scleroderma.
  • To evaluate the effect of SSc on fertility, live birth rates, and fetal wastage.
  • To assess the impact of pregnancy on the course of SSc.

Main Methods:

  • Retrospective analysis of 59 pregnancies in 17 mothers with SSc.
  • Evaluation of fertility, live birth incidence, and fetal wastage.

Related Experiment Videos

  • Assessment of SSc disease activity before, during, and after pregnancy.

    • Main Results:

    • No adverse effect on overall fertility was observed.
    • A decreased incidence of live birth was noted after the onset of SSc.
    • Fetal wastage was attributed equally to spontaneous abortions and induced terminations.
    • Anticardiolipin antibodies were not associated with adverse pregnancy outcomes.
    • Pregnancy outcomes on SSc disease course were variable: stable in 5, regression in 5, progression in 3.

    Conclusions:

    • Pregnancy outcomes in systemic scleroderma are variable.
    • While fertility is generally unaffected, live birth rates may decrease post-SSc diagnosis.
    • Increased pregnancy terminations reflect uncertainty in outcomes for patients and physicians.