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Auditory brain stem evoked potentials in patients with leprosy

O Celik1, S Yalcin, U Gok

  • 1Department of Otorhinolaryngology, Medical Faculty, Firat University, Elazig, Turkey.

International Journal of Leprosy and Other Mycobacterial Diseases : Official Organ of the International Leprosy Association
|June 1, 1997
PubMed
Summary

Leprosy patients treated with dapsone showed significant differences in auditory brain stem evoked potentials (ABEP). This suggests potential auditory pathway damage, highlighting ABEP

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Area of Science:

  • Neuroscience
  • Audiology
  • Infectious Diseases

Background:

  • Leprosy, particularly lepromatous leprosy, can affect the nervous system.
  • Long-standing dapsone treatment in leprosy patients may have neurological implications.
  • Auditory pathway involvement in leprosy is not fully understood.

Purpose of the Study:

  • To electrophysiologically evaluate auditory brain stem evoked potentials (ABEP) in male patients with long-standing lepromatous leprosy treated with dapsone.
  • To compare ABEP findings in leprosy patients with age-matched healthy controls.
  • To investigate potential auditory brain stem pathway involvement in leprosy.

Main Methods:

  • Nineteen male patients with long-standing lepromatous leprosy on dapsone monotherapy were selected.

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  • Electrophysiological evaluation using auditory brain stem evoked potentials (ABEP) was performed.
  • Results were compared to those of 20 age-matched healthy controls.

    • Main Results:

    • Statistically significant differences in ABEP values were observed between leprosy patients and controls.
    • Findings suggest a pathological process primarily affecting auditory brain stem pathways between the cochlear nucleus and lateral lemniscus.
    • These differences were noted in patients with long-standing disease treated with dapsone.

    Conclusions:

    • Auditory brain stem evoked potentials (ABEP) may reveal subclinical auditory pathway dysfunction in lepromatous leprosy.
    • The observed ABEP alterations are consistent with damage in the central auditory pathways.
    • Brain stem evoked response audiometry could be a valuable tool for assessing brain stem involvement in leprosy.