Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A simple design for a small fixed four-electrode brain stimulation array

L Richterich1, J R Stellar

  • 1Department of Psychology, Northeastern University, Boston, MA 02115, USA.

Physiology & Behavior
|August 1, 1997
PubMed
Summary

Researchers developed a novel electrode array for intracranial self-stimulation (ICSS) studies in rats. This innovation allows for repeated testing at multiple sites without causing damage, improving anatomical reward mapping.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Self-control choice with electrical stimulation of the brain as a reinforcer.

Behavioural processes·2014
Same author

c-Fos and deltaFosB expression are differentially altered in distinct subregions of the nucleus accumbens shell in cocaine-sensitized rats.

Neuroscience·2005
Same author

Differential distribution of parvalbumin immunoreactive neurons in the striatum of cocaine sensitized rats.

Neuroscience·2004
Same author

Withdrawal duration differentially affects c-fos expression in the medial prefrontal cortex and discrete subregions of the nucleus accumbens in cocaine-sensitized rats.

Neuroscience·2002
Same author

Effects of isolation-rearing on intracranial self-stimulation reward of the lateral hypothalamus: baseline assessment and drug challenges.

Life sciences·2002
Same author

Neither ibotenic acid nor volkensin lesions of the nucleus accumbens shell affect the expression of cocaine sensitization.

The European journal of neuroscience·2002

Area of Science:

  • Neuroscience
  • Animal Behavior
  • Surgical Instrumentation

Background:

  • Intracranial self-stimulation (ICSS) studies in rats traditionally use lesioning or movable electrodes.
  • These methods have limitations, including the need for repeated testing post-lesion or inability to retest after electrode movement.

Purpose of the Study:

  • To develop a new method for anatomical studies of ICSS reward in rats.
  • To enable repeated behavioral testing at multiple sites within the same animal without causing electrode-induced damage.

Main Methods:

  • A novel array of 4 fixed, vertically-spaced electrodes (0.14-mm Teflon-insulated stainless-steel wire) was constructed.
  • A 4-channel IC rotary switch was implanted for use with a 2-channel electrode lead and commutator.
  • Electrodes were spaced at 0.3 mm, targeting the lateral hypothalamus.

Related Experiment Videos

Main Results:

  • The electrode array allowed for stable rate-frequency curves over a 3-4 month testing period.
  • This method avoids the damage associated with lesioning or movable electrodes, permitting repeated testing.

Conclusions:

  • The fixed, multi-electrode array is a viable tool for anatomical ICSS reward studies in rats.
  • This technique enhances the efficiency and scope of research by enabling multiple stimulation site testing in a single subject.