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Updated: Jul 24, 2026

Ovariectomy and 17β-estradiol Replacement in Rats and Mice: A Visual Demonstration
Published on: June 7, 2012
17beta-Estradiol protects against NMDA-induced excitotoxicity by direct inhibition of NMDA receptors
C E Weaver1, M Park-Chung, T T Gibbs
1Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, MA 02118-2394, USA.
Abstract:
Several lines of evidence suggest that 17beta-estradiol (betaE2) has neuroprotective properties. The risk and severity of dementia are decreased in women who have received estrogen therapy, and betaE2 protects neurons in vitro against death from a variety of stressors. Neuroprotection by betaE2 has been suggested to be due to free radical scavenging. We demonstrate an additional neuroprotective mechanism whereby betaE2 protects against NMDA-induced neuronal death by directly inhibiting the NMDA receptor.
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