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Pregnancy-induced hypertension and hyaline membrane disease
M A Carvalho1, A Faúndes, L C Santos
1Instituto Materno-Infantil de Pernambuco (IMIP), Recife, Brazil.
Objectives:
(1) To determine whether the incidence of hyaline membrane disease (HMD) is different among premature babies of pre-eclamptic women and those of normotensive controls; (2) to determine the relative risk (RR) of HMD according to the severity of pre-eclampsia and gestational age.
Methods:
A retrospective and prospective cohort of 271 pre-eclamptic women and 271 normotensive controls, with gestational age between 28 and 34 weeks was studied, including only singleton pregnancies, live fetuses and well-documented gestational age. Exclusion criteria were ruptured membranes > 24 h, other maternal diseases and previous use of corticosteroids. Statistical analysis included relative risk and multiple logistic regression model.
Results:
The RR of HMD for babies of pre-eclamptic women was 0.96 (95% CI: 0.78-1.17), and remained unchanged after controlling for gestational age and multiple logistic regression analysis.
Conclusion:
Preterm babies of pre-eclamptic mothers had the same probability of having HMD as newborns of normotensive mothers.