Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The stress response and the lung

H R Wong1, J R Wispé

  • 1Division of Critical Care Medicine, Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA.

The American Journal of Physiology
|July 1, 1997
PubMed
Summary

The cellular stress response activates protective stress proteins, like heat shock protein 70, to defend lung cells against injury. Understanding this mechanism may lead to new treatments for acute lung injury.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Pediatric Sepsis Biomarker Risk Model (PERSEVERE) Biomarkers Predict Clinical Deterioration and Mortality in Immunocompromised Children Evaluated for Infection.

Scientific reports·2019
Same author

Extracellular heat shock protein 60 (Hsp60) levels in children with septic shock.

Inflammation research : official journal of the European Histamine Research Society ... [et al.]·2007
Same author

Mechanism and function of heat shock-dependent IkappaBalpha expression.

Inflammation research : official journal of the European Histamine Research Society ... [et al.]·2006
Same author

German cockroach proteases regulate matrix metalloproteinase-9 in human bronchial epithelial cells.

Allergy·2006
Same author

The impact of molecular biology on the practice of pediatric critical care medicine.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·2003
Same author

Protective effects of isohelenin, an inhibitor of nuclear factor kappaB, in endotoxic shock in rats.

Journal of endotoxin research·2002

Area of Science:

  • Cellular Biology
  • Molecular Medicine
  • Pulmonary Medicine

Background:

  • The stress response is a conserved cellular defense mechanism involving the expression of stress proteins.
  • Stress proteins, such as heat shock protein 70 (HSP70) and heme oxygenase-1 (HO-1), are crucial for cellular and tissue protection.
  • Elevated stress protein expression is observed in human lung diseases, including cancer, asthma, and acute lung injury (ALI).

Purpose of the Study:

  • To explore the role of stress proteins in lung biology and their potential protective functions in acute lung injury.
  • To investigate the mechanisms by which stress proteins mediate cytoprotection in lung cells and tissues.
  • To examine the interaction between the stress response and inflammatory pathways in the context of lung injury.

Main Methods:

  • Review of existing literature on stress response, stress proteins, and lung biology.
  • Analysis of studies demonstrating stress protein expression in patients with lung diseases.
  • Examination of cell and animal models of acute lung injury to assess stress protein-mediated protection.

Main Results:

  • Stress protein induction has been shown to protect against acute lung injury in rat models induced by endotoxin or phospholipase A1.
  • In vitro studies indicate that increased stress protein expression protects lung cells from apoptosis and oxidant injury.
  • Evidence suggests stress proteins modulate lung inflammatory responses, potentially through interactions with the I-kappa B/nuclear factor-kappa B (NF-κB) pathway.

Conclusions:

  • Stress proteins play a significant role in protecting lung cells and tissues against various cytotoxic insults.
  • The cytoprotective mechanisms of stress proteins may involve their chaperone and enzymatic activities, as well as the modulation of inflammatory pathways.
  • Further understanding of stress proteins in lung biology could pave the way for therapeutic strategies to enhance their expression for protection against human acute lung injury.

Related Experiment Videos