Non-transferrin-bound iron and tumor cells

The study of iron uptake from low molecular weight complexes by Ehrlich carcinoma cells shows concentration-dependence, and ATP increases the iron uptake from citrate and lactate complexes. Blood proteins can act as inhibitors, and deferoxamine chelation of cell-bound iron complex indicates that the percentage of iron penetrating the cell is about the same for a wide range of iron complex concentrations in the incubation medium (about 5% for ferric lactate). Ascorbic acid increases iron uptake and simultaneously decreases lipid peroxidation. Electrophoresis shows a very high iron transfer from ferric lactate to ATP, and to a lesser extent to ADP and AMP. In the pathological evolution of iron overload to a neoplasia, the probable involvement of an iron exchange between iron complexes from non-transferrin-bound iron of plasma and ATP is discussed.