Gamma-ray scattering for fat fraction measurement

The work reported examines the potential of using gamma-ray photon backscatter information to measure in vivo the percentage of fat in specific tissue volumes. 241Am gamma rays are used as the source and the backscatter detected with a hyperpure germanium detector, with ethanol (approximately 80% fat, 20% muscle) and water (muscle) being used as tissue substitutes. Two measurement techniques are examined; the measurement of the ratio of coherent scatter to Compton scatter and the measurement of the Compton scatter profile. Both are shown to be sensitive to the composition difference between ethanol and water. For the coherent-Compton scatter ratio, the measured difference between water and ethanol is 1.85:1, close to the value calculated (about 2:1). A similar difference in the coherent-Compton ratios between muscle and fat is calculated (2.2:1). The FWHM of the Compton profile has also been shown to vary with tissue composition with a difference of 0.10 keV (5%) between the ethanol and water profile widths.