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Anthelminthic treatment raises plasma iron levels but does not decrease the acute-phase response in Jakarta school

E Karyadi1, R Gross, S Sastroamidjojo

  • 1SEAMEO-TROPMED Regional Center for Community Nutrition, University of Indonesia, Jakarta.

The Southeast Asian Journal of Tropical Medicine and Public Health
|December 1, 1996
PubMed
Summary
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Albendazole treatment significantly reduced intestinal worm infections in Indonesian school children. This deworming also led to a notable increase in plasma iron levels, improving iron status.

Area of Science:

  • Public Health
  • Infectious Diseases
  • Nutritional Science

Background:

  • Intestinal helminthiasis is prevalent in Indonesian school children, impacting their health and nutritional status.
  • High prevalence of Ascaris lumbricoides and Trichuris trichiura infections were observed in the study population.
  • The study aimed to assess the effects of helminthiasis treatment on iron status and acute phase response.

Purpose of the Study:

  • To investigate the impact of intestinal helminthiasis and albendazole treatment on iron status.
  • To evaluate the effect of treatment on the acute phase response (APR) in urban Indonesian primary school children.
  • To determine changes in plasma iron, hemoglobin, and inflammatory markers post-treatment.

Main Methods:

  • A randomized, placebo-controlled trial involving 120 primary school children aged 8-11 years.

Related Experiment Videos

  • Treatment group received a single dose of albendazole (400 mg), while the control group received a placebo.
  • Measurements of plasma iron, hemoglobin, CRP, ESR, WBC, IL-1, IL-6, and TNF were taken before and 10 days after intervention.

    • Main Results:

    • Albendazole treatment drastically reduced ascariasis and trichuriasis prevalence.
    • Plasma iron concentrations and white blood cell (WBC) counts significantly increased in the treatment group post-intervention.
    • Hemoglobin levels showed a non-significant increase, while inflammatory markers remained within normal limits or showed non-specific increases in ESR.

    Conclusions:

    • Albendazole treatment is effective in reducing intestinal worm burden in school children.
    • Treatment with albendazole is associated with improved iron status, indicated by increased plasma iron levels.
    • Further research may be needed to explore the long-term effects on hemoglobin and inflammatory markers.