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Incidence and risk factors for carbohydrate intolerance in Thai infants with acute diarrhea: an outpatient-based
S Osatakul1, S Arunchiya, A Puetpaiboon
1Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand.
Insights
Carbohydrate intolerance affects over 30% of infants with acute diarrhea in Thailand. Risk factors include dehydration, mucus in stools, and rotavirus infection, impacting infant health.
Area of Science:
- Pediatrics
- Infectious Diseases
- Gastroenterology
Background:
- Limited data existed on carbohydrate intolerance in Thai infants with acute diarrhea.
- Acute infantile diarrhea is a common outpatient condition.
Purpose of the Study:
- To determine the incidence of secondary carbohydrate intolerance in outpatients.
- To identify risk factors associated with carbohydrate intolerance in infants.
Main Methods:
- Prospective study conducted at Songklanagarind Hospital.
- Involved 197 well-nourished infants presenting with acute diarrhea.
- Assessed clinical characteristics and identified rotavirus infection.
Main Results:
- Carbohydrate intolerance was found in 31.3% of infants.
- Monosaccharide intolerance was present in 3.5% of affected infants.
- Predictive factors included low bodyweight, dehydration, mucus in stools, and rotavirus.
Conclusions:
- Secondary carbohydrate intolerance is a significant complication of acute infantile diarrhea in Thailand.
- Early identification of risk factors can aid in management.
- Further research may explore specific interventions.
Abstract:
Until recently, information concerning carbohydrate intolerance complicating acute infantile diarrhea of outpatients in Thailand has been lacking. This prospective study was undertaken to determine the incidence and risk factors of secondary carbohydrate intolerance in outpatients. Of 197 well-nourished infants with acute diarrhea who were seen at the outpatient department of Songklanagarind Hospital between July 1991 and June 1992, 62 infants (31.3%) had carbohydrate intolerance, and 7 of the 62 (3.5%) also had acquired monosaccharide intolerance. The clinical characteristics that predicted infants with carbohydrate intolerance were : a low bodyweight relative to the length, dehydration (OR 4.55, 95% CI 1.1.5-17.9), the presence of mucus in diarrheal stools (OR 2.79, 95% CI 1.23-6.32) and rotavirus infection (OR 3.49, 95% CI 1.20-10.18).