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The importance of plasma polymorphonuclear (PMN) elastase determination in patients with uveitis
1Department of Ophthalmology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.
Purpose:
Polymorphonuclear elastase is used as an important marker for inflammatory disease. We wanted to show whether polymorphonuclear elastase could be a marker in uveitis.
Methods:
Twenty-two patients with uveitis and 30 healthy control subjects were included in the study. Polymorphonuclear elastase levels were determined by immunoactivation method before and after periods of corticosteroid and/or cyclosporin treatments.
Results:
The levels were high in all of the patients before treatment; the levels reached normal range with treatment. In some cases, however, uveitis could not be suppressed in spite of treatment; these patients had high polymorphonuclear elastase levels.
Conclusion:
It was concluded that determination of polymorphonuclear elastase level may be used for monitoring of uveitis.