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Phosphoinositide 3-kinases: a conserved family of signal transducers
B Vanhaesebroeck1, S J Leevers, G Panayotou
1Ludwig Institute for Cancer Research, London, UK.
Trends in Biochemical Sciences
|July 1, 1997
Abstract:
Phosphoinositide 3-kinases (PI3Ks) generate lipids that are implicated in receptor-stimulated signalling and in the regulation of membrane traffic. Several distinct classes of PI3Ks have now been identified that have been conserved throughout eukaryotic evolution. Potential signalling pathways downstream of PI3Ks have been elucidated and PI3K function is now being characterised in several model organisms.