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FDG-PET appearance of pelvic Castleman's disease
S P Murphy1, M A Nathan, M W Karwal
1Department of Radiology, University of Iowa College of Medicine, Iowa City, USA.
Summary
Positron emission tomography (PET) imaging with 18F-fluorodeoxyglucose (FDG) showed mild uptake in a pelvic Castleman
Area of Science:
- Oncology
- Nuclear Medicine
- Radiology
Background:
- Castleman's disease is a rare lymphoproliferative disorder.
- Distinguishing Castleman's disease from lymphoma can be challenging.
- Whole-body PET imaging with 18F-fluorodeoxyglucose (FDG) is a valuable tool in oncology.
Observation:
- A case of Castleman's disease presented as a pelvic soft-tissue mass.
- Abdominopelvic CT identified the pelvic mass.
- Whole-body PET imaging demonstrated mild FDG localization within the Castleman's disease.
Findings:
- The standard uptake values (SUV) in this Castleman's disease case were lower than typically reported for low- and intermediate-grade lymphomas.
- This finding suggests a potential difference in metabolic activity between Castleman's disease and certain lymphomas.
Implications:
- FDG-PET imaging may aid in differentiating Castleman's disease from lymphoma.
- Further research is warranted to explore the role of FDG-PET in the diagnosis and management of Castleman's disease.