Related Experiment Videos
Growth-hormone signal transduction
1Department of Physiology, University of Michigan, Ann Arbor, USA.
The Journal of Pediatrics
|July 1, 1997
Summary
Growth hormone (GH) signaling initiates with receptor binding, activating Janus kinase 2 (JAK2). This cascade triggers downstream pathways crucial for cellular functions regulating growth and metabolism.
Area of Science:
- Endocrinology
- Molecular Biology
- Cell Signaling
Background:
- Growth hormone (GH) is a key regulator of postnatal growth.
- Recent advances have elucidated intracellular signaling pathways activated by GH.
- Understanding these pathways is crucial for comprehending GH's biological effects.
Purpose of the Study:
- To detail the intracellular signaling cascade initiated by Growth Hormone (GH) binding.
- To identify the key molecular players and events in GH signal transduction.
- To elucidate how these signaling events modulate cellular functions related to growth and metabolism.
Main Methods:
- The study reviews recent advances in understanding GH intracellular signaling.
- It focuses on the molecular events following GH receptor (GHR) activation.
- The review synthesizes information on the JAK2-STAT pathway and other downstream effectors.
Main Results:
- GH binding causes GHR dimerization, activating associated Janus kinase 2 (JAK2).
- Activated JAK2 phosphorylates GHR and itself, creating docking sites for signaling molecules like STATs, Shc, and IRSs.
- These intermediates activate enzymes (MAP kinase, PI3K) and release second messengers, influencing gene transcription and metabolism.
Conclusions:
- The JAK2-GHR complex is central to GH signal transduction.
- Downstream signaling pathways activated by JAK2 mediate GH's effects on cellular functions.
- This intricate signaling network is essential for GH-dependent control of growth and metabolism.