Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Growth-hormone signal transduction

G S Campbell1

  • 1Department of Physiology, University of Michigan, Ann Arbor, USA.

The Journal of Pediatrics
|July 1, 1997
PubMed
Summary

Growth hormone (GH) signaling initiates with receptor binding, activating Janus kinase 2 (JAK2). This cascade triggers downstream pathways crucial for cellular functions regulating growth and metabolism.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The supratrochleare dorsale accessory ossicle in the elbow.

Journal of shoulder and elbow surgery·2012
Same author

Intra-arterial fluorescein for evaluation of peripheral vascular diseases.

Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)·2010
Same author

Effective lipid modification by partial ileal bypass reduced long-term coronary heart disease mortality and morbidity: five-year posttrial follow-up report from the POSCH. Program on the Surgical Control of the Hyperlipidemias.

Archives of internal medicine·1998
Same author

Regulation of glucose transport and c-fos and egr-1 expression in cells with mutated or endogenous growth hormone receptors.

Endocrinology·1998
Same author

Constitutive activation of JAK1 in Src-transformed cells.

The Journal of biological chemistry·1997
Same author

Signalling pathway of GH.

Endocrine journal·1996

Area of Science:

  • Endocrinology
  • Molecular Biology
  • Cell Signaling

Background:

  • Growth hormone (GH) is a key regulator of postnatal growth.
  • Recent advances have elucidated intracellular signaling pathways activated by GH.
  • Understanding these pathways is crucial for comprehending GH's biological effects.

Purpose of the Study:

  • To detail the intracellular signaling cascade initiated by Growth Hormone (GH) binding.
  • To identify the key molecular players and events in GH signal transduction.
  • To elucidate how these signaling events modulate cellular functions related to growth and metabolism.

Main Methods:

  • The study reviews recent advances in understanding GH intracellular signaling.
  • It focuses on the molecular events following GH receptor (GHR) activation.
  • The review synthesizes information on the JAK2-STAT pathway and other downstream effectors.

Main Results:

  • GH binding causes GHR dimerization, activating associated Janus kinase 2 (JAK2).
  • Activated JAK2 phosphorylates GHR and itself, creating docking sites for signaling molecules like STATs, Shc, and IRSs.
  • These intermediates activate enzymes (MAP kinase, PI3K) and release second messengers, influencing gene transcription and metabolism.

Conclusions:

  • The JAK2-GHR complex is central to GH signal transduction.
  • Downstream signaling pathways activated by JAK2 mediate GH's effects on cellular functions.
  • This intricate signaling network is essential for GH-dependent control of growth and metabolism.

Related Experiment Videos