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[Pathological phosphorus and calcium metabolism during pregnancy and breast feeding]
1Service de rhumatologie, hôpital de La Pitié-Salpêtrière, Paris, France.
Insights
Pregnancy and lactation worsen calcium and vitamin D deficiencies, altering parathyroid disease presentation. Early detection, treatment, and prevention are crucial for maternal and fetal health.
Area of Science:
- Endocrinology
- Obstetrics
- Perinatology
Context:
- Pregnancy and lactation significantly increase risks of calcium and vitamin D deficiencies.
- Gestational changes alter the typical presentation of parathyroid diseases.
- Pregnancy-associated osteoporosis is a specific skeletal disorder observed during gestation.
Purpose:
- To review the early detection and management of endocrine and bone disorders during pregnancy.
- To highlight the impact of maternal deficiencies and diseases on fetal and neonatal outcomes.
- To emphasize preventative strategies for these conditions.
Summary:
- Maternal calcium and vitamin D deficiencies are exacerbated during pregnancy and lactation.
- Parathyroid disease manifestations are modified by gestation, potentially leading to pregnancy-associated osteoporosis.
- Fetus and newborns are vulnerable to the consequences of these maternal health issues.
Impact:
- Informed clinical practice for early identification and intervention.
- Improved maternal and infant health outcomes through targeted prevention.
- Enhanced understanding of the physiological adaptations and risks during pregnancy.
Abstract:
The occurrence of calcium and vitamin D deficiencies is enhanced during pregnancy and lactation. The presentation of parathyroid diseases is altered during gestation. A peculiar form of osteoporosis, pregnancy-associated osteoporosis, may be observed. Fetus and newborns suffer the consequences of all these disorders. The authors have reviewed the early detection and treatment of these diseases and emphasized their prevention.