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Detection of Intracellular Gene Expression in Live Cells of Murine, Human and Porcine Origin Using Fluorescence-labeled Nanoparticles
Published on: November 13, 2015
Native cellular fluorescence and its application to cancer prevention
S P Schantz1, H E Savage, P Sacks
1Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA. schantz@mskcc.ong
Environmental Health Perspectives
|June 1, 1997
Summary
Native cellular fluorescence (NCF) analysis shows potential for distinguishing neoplastic tissues from normal ones. Further research into fluorophores and multiple wavelengths could enhance early cancer screening in the upper aerodigestive tract.
Area of Science:
- Biophotonics
- Medical Optics
- Cancer Diagnostics
Background:
- Native cellular fluorescence (NCF) is the intrinsic light emission property of tissues.
- Advances in optical and computer technology enable in vivo NCF measurement.
- NCF analysis is emerging as a tool for neoplastic tissue characterization.
Purpose of the Study:
- To review the current status of NCF analysis in neoplastic tissues.
- To discuss NCF investigations in the upper aerodigestive tract.
- To highlight the potential of NCF for cancer screening.
Main Methods:
- In vivo measurement of NCF characteristics.
- Analysis of spectral properties across various emission and excitation wavelengths.
- Comparison of NCF signatures between neoplastic and normal tissues.
Main Results:
- Initial findings indicate that NCF analysis can discriminate neoplastic tissues from normal mucosa.
- The biological basis for NCF differences in neoplastic tissues requires further investigation.
- Assessment of multiple wavelengths may improve cancer detection in aerodigestive mucosa.
Conclusions:
- NCF analysis shows promise for differentiating cancerous from healthy tissues.
- Further research is needed to elucidate the underlying fluorophores responsible for observed spectral differences.
- Optimizing NCF assessment with multiple wavelengths could enhance early cancer detection capabilities.
