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Related Experiment Videos

Type of solution and PCO2 measurement errors during tonometry

J J Kolkman¹, L J Zwarekant, K Boshuizen

¹Department of Gastroenterology, Free University Hospital, Amsterdam, The Netherlands. jj.kolkman@inter.nl.net

Intensive Care Medicine

|June 1, 1997

Summary

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Saline and phosphate solutions are suitable for gastrointestinal tonometry, offering a balance between measurement accuracy and equilibration speed. Buffered solutions provide better accuracy but are too slow for clinical use.

Area of Science:

Biomedical Engineering
Medical Device Technology
Clinical Chemistry

Background:

Gastrointestinal tonometry is crucial for assessing tissue PCO2.
The choice of tonometer solution impacts measurement accuracy and speed.
Understanding solution performance is key for reliable clinical application.

Purpose of the Study:

To compare saline with buffered solutions for gastrointestinal tonometry.
To evaluate PCO2 measurement bias, precision, and equilibration time.
To determine systematic and accidental measurement errors for different solutions.

Main Methods:

Prospective laboratory study comparing saline, phosphate, phosphate bicarbonate, and succinylated gelatin solutions.
Equilibration of solutions in a blood gas tonometer at various PCO2 levels.

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Main Results:

Phosphate bicarbonate and gelatin showed slower PCO2 equilibration (4x and 2x slower than saline, respectively).
Saline exhibited a -15% PCO2 bias, while buffered solutions had -1% to 3% bias.
Precision was comparable across solutions; accidental errors were minimal with phosphate bicarbonate.

Conclusions:

Phosphate bicarbonate and gelatin offer accuracy but are too slow for clinical use.
Phosphate offers a bias advantage over saline.
Saline and phosphate are current tonometer solutions of choice with proper anaerobic conditions and known analyzer bias.