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Chronic intestinal infection due to subgenus F type 40 adenovirus in a patient with AIDS

D Dionisio1, S Arista, E Vizzi

  • 1Infectious Diseases Unit, Careggi Hospital, Florence, Italy.

Scandinavian Journal of Infectious Diseases
|January 1, 1997
PubMed

Insights

A prolonged intestinal infection caused by adenovirus type 40 occurred in an AIDS patient. This is the first reported case linking adenovirus type 40 to chronic gastrointestinal issues in immunocompromised individuals.

Area of Science:

  • Infectious Diseases
  • Gastroenterology
  • Virology

Background:

  • Adenoviruses are common causes of gastroenteritis.
  • Immunocompromised individuals, such as those with Acquired Immunodeficiency Syndrome (AIDS), are susceptible to persistent and severe infections.
  • Chronic gastrointestinal symptoms in AIDS patients can be challenging to diagnose.

Observation:

  • A case of chronic intestinal infection lasting 13 months in an AIDS patient is presented.
  • Adenovirus type 40 was identified as the sole enteropathogen.
  • Viral particles were detected in duodenal biopsies via electron microscopy.

Findings:

  • Adenovirus type 40 was confirmed in stool samples using ELISA and monoclonal antibodies.
  • The identified virus was linked to the patient's persistent gastrointestinal symptoms.
  • No other enteropathogens were detected, supporting adenovirus 40 as the causative agent.

Implications:

  • This case highlights adenovirus type 40 as a potential cause of chronic diarrhea in AIDS patients.
  • It underscores the importance of considering uncommon pathogens in immunocompromised individuals.
  • Further research may be warranted on adenovirus type 40 pathogenesis in the context of immunodeficiency.

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