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The effects of substituents introduced into 9-aminoacridine on frameshift mutagenicity and DNA binding affinity
H Tomosaka1, S Omata, E Hasegawa
1Department of Biosystem Science, Graduate School of Science and Technology, Niigata University, Japan.
Bioscience, Biotechnology, and Biochemistry
|July 1, 1997
Abstract:
Some derivatives of 9-aminoacridine (1) were synthesized, and their frameshift mutagenicity and DNA binding affinity were studied. The introduction of a methyl group into the acridine ring of 1 reduced the mutagenic activity and the intercalative DNA binding affinity, while the introduction of chlorine increased them. Halogenated derivatives of 1 showed higher toxicity against Salmonella typhimurium TA1537.