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Insulin-like growth factor-I ameliorates delayed kidney graft function and the acute nephrotoxic effects of

M Maestri1, D C Dafoe, G A Adams

  • 1Department of Surgery, Experimental Surgery, and Institute of Pharmacology, University of Pavia, Italy.

Transplantation
|July 27, 1997
PubMed
Abstract

Insights

Insulin growth factor (IGF)-I and its analog des(1-3)IGF-I show promise in preventing delayed graft function (DGF) after kidney transplants. These treatments improved early graft function and reduced nephrotoxicity in animal models.

Area of Science:

  • Nephrology
  • Immunology
  • Endocrinology

Background:

  • Delayed graft function (DGF) is a common complication in renal transplantation, impacting long-term graft survival.
  • Ischemic injury to the kidney graft is a primary concern in DGF.
  • Current efforts focus on reducing this injury and improving graft recovery.

Purpose of the Study:

  • To evaluate the protective effects of insulin growth factor (IGF)-I and its analog des(1-3)IGF-I on renal transplantation.
  • To assess the impact of these peptides on renal recovery and nephrotoxicity.
  • To determine the potential of IGF-I therapy in clinical settings for DGF and immunosuppressant-induced kidney damage.

Main Methods:

  • Assessed the immunogenicity of des(1-3)IGF-I by examining its effect on skin allograft rejection in Lewis rats.
  • Investigated the influence of des(1-3)IGF-I on early kidney graft function in a DGF model combining warm and cold ischemia.
  • Tested the protective capacity of IGF-I against acute cyclosporine-induced nephrotoxicity.

Main Results:

  • Des(1-3)IGF-I did not significantly affect skin graft rejection (P=0.57).
  • Treatment with des(1-3)IGF-I improved early graft function in a syngenic renal transplant model, with significantly better creatinine and blood urea nitrogen levels (P<0.05).
  • IGF-I treatment ameliorated cyclosporine nephrotoxicity, also showing significant improvements in creatinine and blood urea nitrogen levels (P<0.05).

Conclusions:

  • IGF-I and des(1-3)IGF-I demonstrated beneficial properties in animal models relevant to DGF.
  • These findings suggest that IGF-I and its analog hold potential for preventing clinical DGF.
  • Further research is warranted to explore their clinical applications in renal transplantation.

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