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Gene families consist of groups of genes proposed to have originated from a common ancestor. Typically these arise through events in which a gene or genes are mistakenly duplicated during cell division. Unlike their parent genes (which are subject to selection pressure to maintain function), these gene copies do not need to preserve their sequences and may evolve at a relatively faster rate.
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Alternative RNA Splicing

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Hemoglobin

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Heterozygosity for the IVS-I-5 (G-->C) mutation with a G-->A change at codon 18 (Val-->Met; Hb Baden) in cis and a T-->G mutation at codon 126 (Val-->Gly; Hb Dhonburi) in trans resulting in a thalassemia intermedia.

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Clinical, hematological, and molecular features in Sicilians with Hb S-beta-thalassemia.

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Molecular characterization of beta-thalassemia in Azerbaijan.

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Black beta-thalassemia homozygotes with specific sequence variations in the 5' hypersensitive site-2 of the locus control region have high levels of fetal hemoglobin.

American journal of hematology·1992

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Heterogeneity of the hemoglobin of the Ohrid trout (Salmo L. typicus).

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Haplotypes in SS patients from Nigeria; characterization of one atypical beta S haplotype no. 19 (Benin) associated with elevated HB F and high G gamma levels.

Annals of hematology·1992

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Gamma chain abnormal human fetal hemoglobin variants

¹Medical College of Georgia, Augusta 30912-2114, USA.

American Journal of Hematology

|July 1, 1997

Summary

No abstract available in PubMed .

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