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Updated: Aug 12, 2026

The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse
Published on: May 31, 2016
Abstract:
One of the most challenging diagnostic problems that comes into the physician's office is the patient who complains of "being tired." It can prove to be a frustrating experience for the physician (especially if the physician is also tired) and to the patient. This article will propose and describe a two-pronged systematic approach to the patient that can increase the probability of a satisfying outcome for both physician and patient. This approach assumes the "complaint" of every patient has both informational value ("I think there's something wrong.") and transactional meaning (Please take care of me."). Tiredness, fatigue, "exhaustion" need to be seen simultaneously as information and need. Both aspects require simultaneous work-up.
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