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Peripheral nerve conduction in Miller Fisher syndrome
Journal of Neurology, Neurosurgery, and Psychiatry
|August 1, 1977
Summary
Miller Fisher syndrome, a rare neurological disorder, presents with ophthalmoplegia, ataxia, and arreflexia. Early electrodiagnostic studies reveal peripheral sensory nerve conduction abnormalities, similar to Guillain-Barré syndrome.
Area of Science:
- Neurology
- Neurophysiology
Background:
- Miller Fisher syndrome is a rare variant of Guillain-Barré syndrome characterized by ophthalmoplegia, ataxia, and areflexia.
- Elevated cerebrospinal fluid (CSF) protein is a common finding.
Observation:
- Two cases of acute Miller Fisher syndrome were studied.
- Detailed electrodiagnostic assessments, including electromyography (EMG) and nerve conduction studies (NCS), were performed.
Findings:
- Abnormal conduction in peripheral sensory fibers was detected early in both patients.
- Sensory conduction abnormalities required prolonged follow-up to confirm in one case.
- Electrodiagnostic findings were indistinguishable from those observed in Guillain-Barré syndrome.
- The mechanism of ataxia in Miller Fisher syndrome remains unclear from these electrical findings.
Implications:
- Early electrodiagnostic studies can reveal peripheral sensory involvement in Miller Fisher syndrome.
- The findings highlight the overlap in electrophysiological characteristics between Miller Fisher syndrome and Guillain-Barré syndrome.
- Further research is needed to elucidate the pathophysiology of ataxia in Miller Fisher syndrome.