Related Experiment Videos
Treatment of murine disseminated candidiasis with L-743,872
J R Graybill1, L K Najvar, M F Luther
1University of Texas Health Science Center at San Antonio and Audie Murphy Memorial Veterans Hospital, 78284, USA. GRAYBILL@UTHSCSA.EDU
Antimicrobial Agents and Chemotherapy
|August 1, 1997
Abstract:
L-743,872 (M991), which is a pneumocandin derivative, was evaluated in a mouse model of disseminated candidiasis caused by a fluconazole-resistant isolate of Candida albicans. In immunocompetent mice M991 prolonged survival at doses as low as 0.0125 mg/kg of body weight per day. In neutropenic mice 0.05 mg/kg was the lowest effective dose. M991 is a very potent drug for treatment of disseminated candidiasis.