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Developmental patterns of serum 3 alpha-androstanediol glucuronide

H L Rittner1, P D Lee, W F Blum

  • 1Department of General Pediatrics and Neonatology, Children's Hospital, University of Giessen, Germany.

Journal of Endocrinological Investigation
|May 1, 1997
PubMed
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This study establishes reference ranges for 3 alpha-androstanediol glucuronide (3 alpha diolG) in children and adolescents. These new pediatric reference values for 3 alpha diolG can aid in assessing androgen status.

Area of Science:

  • Endocrinology
  • Pediatric Endocrinology
  • Androgen Metabolism

Background:

  • 3 alpha-androstanediol glucuronide (3 alpha diolG) is a key marker for peripheral androgen metabolism.
  • Complete pediatric reference ranges for 3 alpha diolG have been lacking.
  • Understanding 3 alpha diolG levels is crucial for diagnosing endocrine disorders in children.

Purpose of the Study:

  • To establish comprehensive pediatric reference ranges for serum 3 alpha diolG.
  • To investigate the relationship between 3 alpha diolG levels, age, sex, and pubertal development.
  • To evaluate the utility of 3 alpha diolG as a marker in children with congenital adrenal hyperplasia (CAH).

Main Methods:

  • Serum 3 alpha diolG levels were measured in 283 healthy children/adolescents (1 month-20 years) and 28 adults.

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  • A non-extraction, solid-phase radioimmunoassay with a specific polyclonal antiserum was utilized.
  • Statistical analysis assessed correlations with age, sex, pubertal stage, and clinical status in CAH patients.

    • Main Results:

    • Significant sex and age-dependent variations in 3 alpha diolG levels were observed throughout childhood and adolescence (r=0.8; p<0.0001).
    • Males exhibited significantly higher 3 alpha diolG levels than females (p<0.05).
    • Serum 3 alpha diolG levels correlated significantly with pubertal stage (p<0.01) and clinical/metabolic status in CAH children.

    Conclusions:

    • Percentile curves for 3 alpha diolG in healthy children and adolescents have been successfully established.
    • The established reference values provide a basis for using serum 3 alpha diolG to determine androgen status in pediatric endocrine disorders.
    • Serum 3 alpha diolG shows potential as a valuable diagnostic tool for disorders of puberty and sexual development in children.