No major differences in locomotor responses to dexamphetamine in high and low responders to novelty: a study in Wistar rats

The aim of the study was to compare locomotor responses to acute and sub-chronic dexamphetamine in two distinct types of Wistar rats, namely the Nijmegen high responders to novelty (HR) and Nijmegen low responders to novelty (LR). HR and LR were chosen because they differ in neurochemical processes relevant to the control of the locomotor effects of dexamphetamine, such as the dopaminergic and adrenergic activity in the nucleus accumbens. In experiment 1, a dexamphetamine dose-response curve (0.0-2.0 mg/kg/i.p.) was established using standard activity boxes. The dose-response curve slightly, but significantly, differed between HR and LR: especially the increase elicited by 1.5 mg/kg dexamphetamine was significantly greater in HR than in LR. In experiment 2, locomotor effects of sub-chronic administration of dexamphetamine (1.0 mg/kg/i.p.) were analyzed in HR and LR for 5 consecutive days. HR showed a higher locomotor response to dexamphetamine than LR; however, the two groups did not differ in their sensitization rate. It is concluded that there are neither major HR-LR differences in the locomotor response to acute administration of various doses of dexamphetamine nor HR-LR differences in the rate of sensitization of this locomotor response to sub-chronic administration of dexamphetamine. Type-specific differences in the mutual interaction between corticosteroids and dexamphetamine as well as the nature of the chosen dependent variable, namely locomotor activity, are hypothesized to underlie the results of the present study.