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Contact angles of pharmaceutical powders
Journal of Pharmaceutical Sciences
|October 1, 1977
Summary
Contact angles of pharmaceutical powders were measured using a novel drop height method. This study presents contact angle results for various drug substances, offering insights into powder wettability.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
- Physical Chemistry
Background:
- Understanding powder wettability is crucial for pharmaceutical formulation.
- Contact angle measurements provide key insights into powder-surface interactions and liquid penetration.
Purpose of the Study:
- To determine the contact angles of various pharmaceutical powders.
- To establish a reliable method for measuring contact angles on presaturated powder compacts.
Main Methods:
- Developed a method measuring the maximum height of a saturated solution drop on a presaturated powder compact.
- Applied this technique to a series of pharmaceutical drug materials.
Main Results:
- Successfully measured contact angles for a range of pharmaceutical powders.
- The results provide quantitative data on the wettability of these drug substances.
Conclusions:
- The described method is effective for determining pharmaceutical powder contact angles.
- The presented data can inform formulation development and processing of these drugs.