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Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models
Published on: August 9, 2012
Cystectomy and urinary diversion
1Department of Urology, General Infirmary at Leeds, United Kingdom.
Abstract:
New insights into bladder cancer mechanisms have not yet produced clinical benefit. Without novel treatments, cystectomy remains the most effective local treatment, albeit the most aggressive. Uncertainty about the natural history of bladder cancer, the progression rate after other treatments, the risks of cystectomy and subsequent quality of life, foster debate about the indications for cystectomy. There are numerous urinary diversions and bladder substitutes. Differences in tumour extent, patient age, performance status, renal and mental function, and acceptance make different diversion techniques necessary. Urologists need not know every technique, but should know at least one technique of each class: an incontinent diversion (such as the ileal conduit), ureterosigmoidostomy, continent reservoir, and orthotopic bladder substitute. The common principles, advantages, and contraindications of these techniques are discussed.
Insights
Radical cystectomy is the most effective treatment for bladder cancer but remains aggressive. Understanding urinary diversion techniques is crucial for urologists to manage patient needs and optimize outcomes.
Area of Science:
- Urology
- Oncology
- Surgical Innovation
Background:
- Current bladder cancer treatments lack novel clinical benefits.
- Radical cystectomy is the most effective local treatment but is highly aggressive.
- Uncertainty regarding bladder cancer's natural history and cystectomy risks fuels debate on its indications.
Purpose of the Study:
- To discuss the necessity and variety of urinary diversion techniques post-cystectomy.
- To highlight the importance of understanding different diversion classes for urologists.
- To provide an overview of principles, advantages, and contraindications for various urinary diversions.
Main Methods:
- Review of existing literature on bladder cancer treatment and urinary diversion.
- Discussion of common principles, advantages, and contraindications of different diversion techniques.
- Categorization of diversions into incontinent diversion, ureterosigmoidostomy, continent reservoir, and orthotopic bladder substitute.
Main Results:
- Numerous urinary diversion and bladder substitute options exist.
- Patient-specific factors (tumor extent, age, function, acceptance) necessitate varied techniques.
- Urologists should be proficient in at least one technique from each major diversion class.
Conclusions:
- Effective management of bladder cancer requires careful consideration of cystectomy and subsequent urinary diversion.
- A foundational understanding of various urinary diversion techniques is essential for urologists.
- Tailoring diversion techniques to individual patient profiles is critical for optimizing quality of life post-cystectomy.
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