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The prevalence of hepatitis C in survivors of paediatric malignancy
T L Carter1, C H Cole, C F Mews
1Haematology/Oncology Department, Princess Margaret Hospital for Children, Subiaco, Western Australia.
Objective:
To assess the prevalence of hepatitis C in 200 patients with paediatric malignancies, surviving in remission more than 5 years from diagnosis, who had received blood product transfusions before 1990 when routine screening of blood products for hepatitis C began.
Method:
The second and third generation Abbott Diagnostics ELISA was used to assess hepatitis C seropositivity. Seropositive patients and those with abnormal liver transaminases were assessed by hepatitis C virus RNA polymerase chain reaction (PCR).
Results:
A low incidence (4%) of seropositivity for hepatitis C was found in survivors of paediatric malignancy who were transfused prior to routine screening of blood products in this cohort.
Conclusions:
All patients identified have evidence of hepatitis and may be at high risk of developing cirrhosis.
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