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Related Experiment Videos

Long circulating biodegradable poly(phosphazene) nanoparticles surface modified with poly(phosphazene)-poly(ethylene

J Vandorpe1, E Schacht, S Dunn

  • 1Department of Organic Chemistry, Biomaterials and Polymer Research Group, University of Ghent, Belgium.

Biomaterials
|September 1, 1997
PubMed
Summary

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Biodegradable nanoparticles coated with PF-PEO[5000] show prolonged circulation and reduced liver uptake compared to Poloxamine 908. This surface modification is crucial for enhanced nanoparticle biodistribution and potential targeting.

Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Pharmacokinetics

Background:

  • Biodegradable nanoparticles are promising drug delivery vehicles.
  • Surface modification influences nanoparticle biodistribution and circulation time.
  • Poly(organo phosphazene) and poly(lactide-co-glycolide) are common nanoparticle materials.

Purpose of the Study:

  • To investigate the biodistribution of poly(organo phosphazene) nanoparticles surface-modified with a novel poly(organo phosphazene)-poly(ethylene oxide) copolymer (PF-PEO[5000]).
  • To compare the biodistribution of PF-PEO[5000]-coated nanoparticles with those coated with a commercial copolymer (Poloxamine 908).
  • To assess the impact of surface modification on nanoparticle circulation time and organ uptake in vivo.

Main Methods:

  • Intravenous administration of nanoparticles to rats and rabbits.

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  • Biodistribution studies using quantitative analysis of nanoparticle distribution in various organs.
  • Comparison of nanoparticle clearance rates and tissue sequestration between different surface coatings.

    • Main Results:

    • Poly(organo phosphazene) nanoparticles coated with Poloxamine 908 were primarily captured by the liver.
    • PF-PEO[5000]-coated poly(organo phosphazene) nanoparticles exhibited prolonged blood circulation and reduced liver sequestration.
    • In rabbits, PF-PEO[5000]-coated nanoparticles showed extended systemic circulation and significant targeting to the bone marrow.

    Conclusions:

    • The nature of the nanoparticle surface coating significantly impacts biodistribution and pharmacokinetic profiles.
    • PF-PEO[5000] surface modification enhances nanoparticle circulation time and reduces undesirable liver uptake.
    • Surface-engineered nanoparticles hold potential for targeted delivery, including to bone marrow.