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Pregnancy outcome following donor embryo replacement
R P Porreco1, C L Schoolcraft, W B Schoolcraft
1HealthONE Perinatal Services, Denver, Colorado, USA.
The Journal of Maternal-Fetal Medicine
|July 1, 1997
Summary
Donor embryo pregnancies show no increased risk of adverse perinatal outcomes compared to standard in vitro fertilization (IVF) pregnancies. This study found similar rates of complications, suggesting donor embryos are safe for conception.
Area of Science:
- Reproductive Medicine
- Perinatal Health
- Assisted Reproductive Technology
Background:
- Donor embryo transfers are an option for infertility treatment.
- Perinatal outcomes in donor embryo pregnancies require careful evaluation.
Purpose of the Study:
- To compare adverse perinatal outcomes between donor embryo pregnancies and standard in vitro fertilization (IVF) pregnancies.
Main Methods:
- A retrospective study compared 35 donor embryo pregnancies with 32 age-matched control IVF pregnancies.
- Exclusion criteria included multifetal pregnancy reduction.
- Data on spontaneous abortion, cesarean birth, birthweight, gestational age, preterm birth, and preeclampsia were analyzed.
Main Results:
- Spontaneous abortion rates were 34% (donor) and 25% (control IVF).
- No significant differences were observed in cesarean births, birthweights, or gestational ages.
- Preterm birth and preeclampsia rates were similar between groups, with over one-third experiencing adverse outcomes (preterm birth +/- preeclampsia).
Conclusions:
- Donor embryo pregnancies do not exhibit an increased risk of adverse perinatal outcomes compared to age-matched IVF controls.
- The data do not exclude a modest increase in adverse outcomes, warranting continued monitoring.