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Hyaluronan in morphogenesis

B P Toole1

  • 1Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, MA, USA. btoole@infonet.tufts.edu

Journal of Internal Medicine
|July 1, 1997
PubMed
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Hyaluronan is key in embryonic development, facilitating cell movement and tissue regeneration. Its interactions with receptors like CD44 and RHAMM are vital for cell invasion and proliferation during morphogenesis.

Area of Science:

  • Developmental Biology
  • Cell Biology
  • Biochemistry

Background:

  • Pericellular matrices, enriched in hyaluronan, surround cells during embryonic development, tissue regeneration, and tumor invasion.
  • Hyaluronan interacts with cell surface receptors, notably RHAMM (Receptor for Hyaluronan-Mediated Motility) and CD44.
  • These interactions play crucial roles in dynamic cellular processes.

Purpose of the Study:

  • To elucidate the multifaceted roles of hyaluronan-cell surface receptor interactions during morphogenesis.
  • To understand hyaluronan's contribution to pericellular matrix structure and its functional implications.
  • To investigate the involvement of hyaluronan-RHAMM/CD44 signaling in cell migration, proliferation, and invasion.

Main Methods:

  • Analysis of pericellular matrices in developing embryos and regenerating tissues.

Related Experiment Videos

  • Investigation of hyaluronan-CD44 interactions in endocytic removal during development.
  • In vitro studies examining hyaluronan interactions with RHAMM and CD44 to assess effects on cell movement and proliferation.

    • Main Results:

    • Hyaluronan-CD44 interactions mediate the removal of hyaluronan at critical developmental stages.
    • The hydrated pericellular environment created by hyaluronan supports cellular invasion.
    • In vitro evidence strongly suggests hyaluronan-RHAMM/CD44 signaling is essential for cell movement and proliferation.

    Conclusions:

    • Hyaluronan is integral to the pericellular matrix, influencing cell behavior during development and disease.
    • Interactions between hyaluronan and its receptors (CD44, RHAMM) are critical regulators of cell migration, proliferation, and tissue remodeling.
    • Understanding these molecular mechanisms provides insights into embryonic morphogenesis and pathological conditions like tumor invasion.