Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Irreversible lithium neurotoxicity: an overview

B Kores1, M H Lader

  • 1Department of Psychiatry, University Medical Center Ljubljana, Slovenia.

Clinical Neuropharmacology
|August 1, 1997
PubMed
Summary

Lithium toxicity can cause serious, persistent neurologic problems like ataxia and dysarthria. Patient education and careful prescribing are key to avoiding these severe side effects.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Physiological and psychological effects of ±-propranolol, +-propranolol and diazepam in induced anxiety.

British journal of clinical pharmacology·2012
Same author

Physiological response to propranolol and diazepam in chronic anxiety.

British journal of clinical pharmacology·2012
Same author

Commentary on 'Flumazenil-precipitated panic and dysphoria in patients dependent on benzodiazpines: a possible aid to abstinence'.

Journal of psychopharmacology (Oxford, England)·2012
Same author

Central benzodiazepine receptor imaging and quantitation with single photon emission computerised tomography: SPECT.

Journal of psychopharmacology (Oxford, England)·2012
Same author

The effects of D-fenfluramine on mood and performance, and on neuroendocrine indicators of 5-HT function.

Journal of psychopharmacology (Oxford, England)·2012
Same author

A pilot study of the effects of flumazenil on symptoms persisting after benzodiazepine withdrawal.

Journal of psychopharmacology (Oxford, England)·2012

Area of Science:

  • Neurology
  • Pharmacology
  • Toxicology

Background:

  • Lithium is a common mood stabilizer with well-documented side effects.
  • Persistent neurologic sequelae are rare but serious complications of lithium toxicity.

Observation:

  • Neurologic dysfunction can occur after acute overdose or insidious toxicity during maintenance therapy.
  • Cerebellar signs, including ataxia and dysarthria, are the most common irreversible sequelae.

Findings:

  • Risk factors for persistent neurologic sequelae are not always identifiable.
  • These handicaps significantly impair quality of life and are challenging to manage.

Implications:

  • Conservative prescribing and patient education are crucial for preventing lithium toxicity.
  • Recognizing early signs of toxicity in patients and caregivers is essential for timely intervention.

Related Experiment Videos