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Related Experiment Videos

Peripheral autonomic nerve dysfunction in asymptomatic leprosy contacts

E Wilder-Smith1, A Wilder-Smith, M Egger

  • 1Department of Neurology, University of Berne, Switzerland.

Journal of the Neurological Sciences
|September 1, 1997
PubMed
Summary
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Subclinical autonomic nerve dysfunction is common in asymptomatic leprosy contacts. Early detection through vasomotor reflex testing may identify individuals at risk before clinical symptoms appear.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Public Health

Background:

  • Subclinical autonomic nerve dysfunction may precede clinical leprosy.
  • Early detection of leprosy complications is crucial in endemic areas.

Purpose of the Study:

  • To investigate subclinical autonomic neuropathy in asymptomatic leprosy contacts.
  • To assess the utility of vasomotor reflex (VMR) testing for early leprosy detection.

Main Methods:

  • Vasomotor reflex (VMR) testing using laser doppler velocimetry.
  • Assessed microvascular blood flow changes in finger and toe tips following an inspiratory gasp.
  • Compared VMR results between 36 asymptomatic leprosy contacts and 47 healthy controls in Nepal.

Main Results:

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  • Abnormal VMR test results were significantly more prevalent in household contacts (54%) and hospital contacts (42%) compared to controls (15%).
  • A significant difference in mean percent reduction of microvascular blood flow was observed across the groups (p=0.001).
  • The prevalence of abnormal VMR tests showed a significant trend across the contact and control groups (p=0.0005).

Conclusions:

  • Subclinical autonomic neuropathy is prevalent in healthy individuals with exposure to leprosy.
  • VMR testing may serve as a valuable tool for identifying individuals at risk of developing clinical leprosy.
  • Further prospective studies are warranted to determine the predictive value of abnormal VMR tests for disease progression.