Related Experiment Video

Updated: Aug 8, 2026

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
07:13

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

Published on: April 12, 2021

Growth rates in pediatric dialysis patients and renal transplant recipients

M N Turenne1, F K Port, R L Strawderman

  • 1United States Renal Data System Coordinating Center and Department of Medicine, University of Michigan, Ann Arbor 48103, USA. usrds@umich.edu

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
|August 1, 1997
PubMed

Insights

Pediatric kidney transplant patients showed faster growth than dialysis patients, especially in younger children. Growth rates varied by age and dialysis type, with no significant pubertal growth spurt observed.

Area of Science:

  • Pediatric Nephrology
  • Growth and Development
  • Renal Replacement Therapy

Background:

  • Pediatric end-stage renal disease (ESRD) impacts growth and development.
  • Understanding growth differences between renal replacement therapies is crucial for optimizing patient outcomes.

Purpose of the Study:

  • To compare pediatric growth rates across different renal replacement modalities: transplantation, hemodialysis, continuous cycling peritoneal dialysis (CCPD), and chronic ambulatory peritoneal dialysis (CAPD).
  • To analyze age-specific differences in growth rates among pediatric ESRD patients.

Main Methods:

  • A retrospective analysis of 1,302 US pediatric ESRD patients treated in 1990.
  • Linear regression models adjusted for age, sex, race, ethnicity, and ESRD duration.
  • Stratification by age groups: 0.5-4, 5-9, 10-14, and 15-18 years.

Main Results:

  • Younger children (0.5-9 years) exhibited significantly higher growth rates with transplantation compared to all dialysis modalities.
  • Older children (10-18 years) showed no significant growth rate differences between transplantation and dialysis.
  • Among dialysis modalities, older CAPD patients demonstrated faster growth than hemodialysis or CCPD patients.
  • Alternate-day steroid use in transplant recipients correlated with faster growth, independent of allograft function.
  • No substantial pubertal growth spurt was observed in either transplant or dialysis patients.

Conclusions:

  • Growth rates in pediatric ESRD patients vary significantly by age and treatment modality.
  • Kidney transplantation promotes better growth in younger children compared to dialysis.
  • Dialysis modality choice may influence growth, particularly in older pediatric patients.

More Related Videos

Robot-Assisted Kidney Transplantation07:30

Robot-Assisted Kidney Transplantation

Published on: July 19, 2021

A Retrograde Implantation Approach for Peritoneal Dialysis Catheter Placement in Mice06:27

A Retrograde Implantation Approach for Peritoneal Dialysis Catheter Placement in Mice

Published on: July 20, 2022

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration01:28

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration

Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area. This equation is...
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...