Liver involvement and its course in experimental colitis in rats
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Published on: February 27, 2014
11st Department of Surgery, University of Medicine, Wroclaw, Poland.
Background/Aim:
The aim of the study was to evaluate histological liver lesions and to compare these with the results of biochemical parametres.
Methodology:
An experimental model of chronic ulcerative colitis in rats was utilized.
Results:
Histological studies of the biliary tree showed progressive fibrotic inflammation which fulfilled the criteria of early sclerosing cholangitis. The biochemical tests of liver function were, however normal in all animals.
Conclusions:
Sclerosing cholangitis in experimental ulcerative colitis is a progressive disease, and normal liver biochemistry does not exclude changes in liver histology.

