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Updated: Aug 15, 2026

High-Resolution Endocardial and Epicardial Optical Mapping in a Sheep Model of Stretch-Induced Atrial Fibrillation
Published on: July 29, 2011
The seventh annual Gordon K. Moe Lecture. Atrial fibrillation: from cell t bedside
1Indiana University School of Medicine, Department of Medicine, Krannert Institute of Cardiology, Roudebush Veterans Affairs Medical Center, Indianapolis 46202, USA.
Abstract:
Atrial fibrillation is the most common sustained tachyarrhythmia and, as such, has become the recent focus of intense clinical and experimental interest. Because of its associated morbidity and mortality, there is a multidisciplinary effort to understand the pathophysiology that may ultimately lead to improved therapeutic options. This review concentrates on three aspects of atrial fibrillation that influence contemporary choices for treatment: an electrophysiologic basis for initiation of atrial fibrillation, anatomic and electrophysiologic remodeling, and concepts regarding its termination or prevention.
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