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Related Experiment Videos

How to decrease false-positive cases of ovarian cancer screening by transvaginal sonography

T Misawa1, M Asai, K Higashide

  • 1Dept. of Obstetrics and Gynecology, Chita City Hospital, Japan.

Journal of Experimental & Clinical Cancer Research : CR
|June 1, 1997
PubMed
Summary
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Transvaginal sonography (TVS) detected ovarian tumors in 4.2% of asymptomatic women. Many detected ovarian cysts resolved on repeat screening, highlighting the need for careful interpretation in ovarian cancer screening.

Area of Science:

  • Gynecologic Oncology
  • Medical Imaging
  • Preventive Medicine

Background:

  • Ovarian cancer screening is crucial for reducing mortality.
  • Transvaginal sonography (TVS) is a key imaging modality for ovarian cancer detection.

Purpose of the Study:

  • To report the findings of ovarian cancer screening using TVS in asymptomatic women.
  • To evaluate the detection rate and characteristics of ovarian tumors identified via TVS.

Main Methods:

  • Screening of 2,095 asymptomatic women using transvaginal sonography (TVS) over four years.
  • Detection and morphological classification of ovarian tumors (>30 mm diameter).
  • Correlation of TVS findings with palpation and pathological diagnoses after laparotomy.

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Main Results:

  • Ovarian tumors were detected in 87 women (4.2%).
  • 14 tumors were complex type, 73 were cystic type; only 12 were palpable.
  • Pathological diagnoses included 1 ovarian cancer, 3 dermoid cysts, 4 endometrioid cysts, and 1 paraovarian cyst.
  • Many detected tumors, especially cystic types under 50 mm, resolved on repeat TVS, particularly during prolonged menstrual cycles.

Conclusions:

  • TVS can detect ovarian tumors in asymptomatic women.
  • Careful consideration of menstrual cycle phase and tumor morphology is essential to minimize false-positive results in TVS screening.
  • Further evaluation is needed for complex ovarian masses detected during screening.