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Related Experiment Videos

Medullary thick limb basolateral Cl- channels

W B Reeves1, C J Winters, L Zimniak

  • 1Department of Internal Medicine, University of Arkansas College of Medicine, Little Rock, USA.

Wiener Klinische Wochenschrift
|June 27, 1997
PubMed
Summary

Chloride channels in the kidney

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Area of Science:

  • Nephrology
  • Renal Physiology
  • Molecular Biology

Background:

  • Chloride transport in the medullary thick ascending limb is crucial for kidney function.
  • This transport influences urinary concentrating/diluting ability and tubuloglomerular feedback.

Purpose of the Study:

  • To review the features of a specific chloride channel in the kidney.
  • To identify the molecular identity of this basolateral chloride channel.

Main Methods:

  • Review of functional and immunohistochemical data.
  • Discussion of electrophysiologic and regulatory properties.

Main Results:

  • Evidence suggests a specific Cl- channel in the basolateral membrane.
  • The cloned channel rbCIC-Ka from rabbit kidney medulla is a likely candidate.

Conclusions:

  • rbCIC-Ka may be the primary chloride channel responsible for basolateral efflux in the medullary thick ascending limb.
  • Understanding this channel is key to comprehending renal concentrating mechanisms.

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