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Apolipoprotein B gene polymorphisms in Taiwanese ischemic stroke patients
1Department of Neurology, National Cheng Kung University Hospital, Tainan, Taiwan, ROC.
Summary
The AluI restriction fragment length polymorphism (RFLP) in the apolipoprotein B (apoB) gene showed no significant association with ischemic stroke occurrence. However, the rare AluI RFLP (A+ allele) was linked to higher apoB levels in stroke patients.
Area of Science:
- Genetics
- Cardiovascular Disease Epidemiology
- Molecular Biology
Background:
- Apolipoprotein B (apoB) is crucial for lipoprotein metabolism and is a known risk factor for ischemic stroke.
- Restriction fragment length polymorphisms (RFLPs) in genes like apolipoprotein B (apoB) can influence protein levels and disease risk.
Purpose of the Study:
- To investigate the association between the AluI allelic distribution of the apolipoprotein B (apoB) gene and the incidence of ischemic stroke in a Taiwanese population.
- To explore the relationship between specific AluI RFLPs and plasma apoB levels in ischemic stroke patients.
Main Methods:
- Analysis of AluI restriction fragment length polymorphism (RFLP) in the apolipoprotein B (apoB) gene.
- Comparison of allele and genotype frequencies between 159 ischemic stroke patients and 44 healthy controls.
- Statistical analysis to determine associations between RFLP and apoB levels.
Main Results:
- No significant difference in AluI allele (A-) frequencies (0.87 vs. 0.89) or genotype distributions (A-/A-, A-/A+, A+/A+) between ischemic stroke patients and controls.
- A significant association was found between the rare AluI RFLP (A+ allele) and elevated apoB levels specifically within the ischemic stroke patient group.
Conclusions:
- The AluI RFLP itself does not appear to be a significant risk factor for ischemic stroke occurrence in this Taiwanese cohort.
- The presence of the rare AluI RFLP (A+ allele) may be associated with increased plasma apoB levels, a known risk factor for ischemic stroke.