Related Experiment Videos
Pattern of motor neurone disease in eastern India
S P Saha1, S K Das, P K Gangopadhyay
1Department of Neuromedicine, Bangur Institute of Neurology, Calcutta, India.
Acta Neurologica Scandinavica
|July 1, 1997
Summary
This study analyzed motor neurone disease (MND) patterns in Eastern India, finding amyotrophic lateral sclerosis (ALS) and monomelic amyotrophy (MMA) were most common. The research highlights demographic and clinical variations in MND subtypes.
Area of Science:
- Neurology
- Clinical Epidemiology
Background:
- Motor neurone disease (MND) encompasses a group of progressive neurodegenerative disorders.
- Understanding the epidemiological patterns of MND is crucial for diagnosis and management.
Purpose of the Study:
- To investigate the clinical patterns and prevalence of different motor neurone disease subtypes in Eastern India.
- To identify demographic, clinical, and etiological factors associated with MND in the studied population.
Main Methods:
- A clinical study conducted from July 1993 to June 1995.
- Involved analysis of 110 motor neurone disease cases at Bangur Institute of Neurology and SSKM Hospital, Calcutta.
- Included clinical assessment, electrophysiological studies (EMG), and neuroimaging.
Main Results:
- Amyotrophic lateral sclerosis (ALS) was the most frequent subtype (43.6%), followed by monomelic amyotrophy (MMA) (22.7%) and spinal muscular atrophy (SMA) (20%).
- MND was more prevalent in males, with symptom duration ranging from 1 to 12 months.
- MMA and SMA predominantly affected individuals under 30, while ALS and progressive muscular atrophy (PMA) presented after 30. Trauma was a common antecedent event in ALS and MMA.
- EMG typically showed neurogenic or mixed patterns; neuroimaging primarily excluded compressive lesions.
Conclusions:
- Monomelic amyotrophy (MMA) is not rare in Eastern India compared to other regions.
- The study provides valuable insights into the heterogeneity of motor neurone disease presentation in Eastern India.
- Further research is needed to understand the specific etiological factors and genetic predispositions in this region.