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Effect of chronic clozapine administration on [3H]MK801-binding sites in the rat brain: a side-preference action in
L Giardino1, F Bortolotti, C Orazzo
1Institute of Otolaryngology II, University of Milan, Italy. cefisnmo@mbox.vol.it
Brain Research
|July 11, 1997
Abstract:
We studied modifications in [3H]MK801-binding sites in the rat brain after chronic clozapine. We found a 20-30% reduction of [3H]MK801-binding sites in the anterior cingulate, frontoparietal motor and frontoparietal somatosensory cortices on the left side but none on the right. We also demonstrated a 20% bilateral increase of N-methyl-D-aspartate (NMDA) receptors in the dentate gyrus of the hippocampus. No changes were found in the prefrontal cortex, caudate-putamen, nucleus accumbens, hippocampus or olfactory tubercle.