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Related Experiment Videos

Flow-induced vasodilation in the ferret lung

J H Chammas1, D A Rickaby, M Guarin

  • 1Department of Surgery, Medical College of Wisconsin, Milwaukee 53226, USA.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|August 1, 1997
PubMed
Summary

Shear stress may stimulate pulmonary vasodilation. In isolated ferret lungs, increased blood flow dilated small pulmonary arteries under hypoxic conditions, suggesting shear stress is a vasodilator.

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Area of Science:

  • Pulmonary circulation physiology
  • Vascular mechanics

Background:

  • Pulmonary arteries regulate blood flow and pressure.
  • Vascular tone influences pulmonary artery diameter.

Purpose of the Study:

  • To investigate if shear stress acts as a pulmonary vasodilator.
  • To determine the effect of blood flow changes on small pulmonary artery diameter.

Main Methods:

  • Isolated perfused ferret lung lobes were used.
  • Microfocal X-ray imaging measured arterial diameters (0.3-1.3 mm).
  • Blood flow was altered (10 vs. 40 ml/min) at constant pressure under normoxic and hypoxic conditions.

Main Results:

  • Under normoxia, flow changes had minimal effect on arterial diameter.

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  • Under hypoxia, higher blood flow led to larger arterial diameters at constant pressure.
  • Results indicate shear stress is a pulmonary vasodilator stimulus.

    • Conclusions:

    • Shear stress is a potential stimulus for pulmonary vasodilation.
    • This mechanism may play a role in regulating pulmonary blood flow.