Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Acid-base regulation after maximal exercise testing in late gestation

J G Kemp1, F A Greer, L A Wolfe

  • 1Department of Physiology, School of Physical and Health Education, Queen's University, Kingston, Ontario, Canada K7L 3N6.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|August 1, 1997
PubMed
Summary

Pregnancy alters plasma acid-base balance, with pregnant women showing lower plasma acidity (H+) during rest and after strenuous exercise compared to non-pregnant individuals. This is due to changes in PCO2 and strong ion difference.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Biallelic mutations in mitochondrial tryptophanyl-tRNA synthetase cause Levodopa-responsive infantile-onset Parkinsonism.

Clinical genetics·2017
Same author

Morphological and biochemical alterations of skeletal muscles from the genetically obese (ob/ob) mouse.

International journal of obesity (2005)·2009
Same author

Essential fatty acid profiling for routine nutritional assessment unmasks adrenoleukodystrophy in an infant with isovaleric acidaemia.

Journal of inherited metabolic disease·2008
Same author

Orphan seven transmembrane receptor screening.

Ernst Schering Foundation symposium proceedings·2007
Same author

Plasma osmolality and the strong ion difference predict respiratory adaptations in pregnant and nonpregnant women.

Canadian journal of physiology and pharmacology·2003
Same author

Physicochemical analysis of phasic menstrual cycle effects on acid-base balance.

American journal of physiology. Regulatory, integrative and comparative physiology·2001

Area of Science:

  • Physiology
  • Biochemistry
  • Exercise Science

Background:

  • Pregnancy significantly alters maternal physiology.
  • Understanding acid-base balance during exercise in pregnancy is crucial for maternal and fetal health.

Purpose of the Study:

  • To quantify the effects of pregnancy and strenuous exercise on plasma hydrogen ion concentration ([H+]) using Stewart's physicochemical approach.
  • To investigate the independent determinants of plasma [H+] in pregnant women compared to non-pregnant controls.

Main Methods:

  • Employed Stewart's physicochemical approach to analyze blood samples and respiratory data.
  • Recruited physically active pregnant women and age-matched non-pregnant controls.
  • Collected data at rest and during 15-minute recovery from maximal cycle ergometer tests.

Related Experiment Videos

Main Results:

  • Both groups showed increased [H+], PCO2, and total protein, with decreased [HCO-3] and [SID] from rest to maximal exercise.
  • Pregnant women had lower resting and post-exercise PCO2, [HCO-3], and total protein.
  • Pregnant women exhibited lower [SID] at rest and early recovery, and lower [H+] overall, significantly at rest.

Conclusions:

  • Reduced PCO2 and weak acid concentration are key mechanisms regulating plasma [H+] in late gestation.
  • Pregnancy establishes a less acidic plasma environment at rest, maintained after maximal exertion.
  • Physicochemical principles effectively explain observed acid-base differences between pregnant and non-pregnant states during exercise.